InSolutionTM G-Secretase Inhibitor X - 炼石商城

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InSolutionTM G-Secretase Inhibitor X

市场价：: 0.00

促销价：: ¥0.00

货号：565771-500UG

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula
C₃₉H₅₂N₄O₆

Description
Overview	A cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβ_total IC₅₀ = 17 nM, Aβ₄₀ IC₅₀ = 48 nM, and Aβ₄₂ IC₅₀ = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
Catalogue Number	565771
Brand Family	Calbiochem®
Synonyms	L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester

References
References	Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
Hill Formula	C₃₉H₅₂N₄O₆
Chemical formula	C₃₉H₅₂N₄O₆
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	Aβ_total
Primary Target IC<sub>50</sub>	Aβtotal 17 nM, Aβ40 48 nM, and Aβ42 67 nM in SHSY5Y cells overexpressing spβA4CTF
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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