PKC 20-28, Cell-Permeable, Myristoylated - 炼石商城

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PKC 20-28, Cell-Permeable, Myristoylated

市场价：: 0.00

促销价：: ¥0.00

货号：476480-500UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula
C₆₀H₁₀₆N₁₈O₁₁

Description
Overview	Pseudosubstrate sequence from protein kinase C_α and β ( PKC_α and PKC_β). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀= 8 µM); exhibits 98% inhibition at 100 µM.
Catalogue Number	476480
Brand Family	Calbiochem®
Synonyms	Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH₂, Protein Kinase C 20-28, Cell-Permeable, Myristoylated

References
References	Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982. Ward, N.E. and O’Brian, C.A. 1993. Biochemistry 32, 11903.

Product Information
ATP Competitive	N
Form	Lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₆₀H₁₀₆N₁₈O₁₁
Chemical formula	C₆₀H₁₀₆N₁₈O₁₁
Hygroscopic	Hygroscopic
Reversible	Y
Sold on the basis of peptide content	Y

Applications

Biological Information
Primary Target	TPA activation of MARCKS phosphorylation in fibroblast primary cultures
Primary Target IC<sub>50</sub>	8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Content	Y
Peptide Sequence	N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

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