Replacement Information |
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Empirical Formula |
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C₂₅H₂₄O₁₂ |
Description | |
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Overview | A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. The solid form (Cat. No. 559285) is also available. |
Catalogue Number | 559292 |
Brand Family | Calbiochem® |
Product Information | |
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Form | Liquid |
Formulation | A 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO. |
Hill Formula | C₂₅H₂₄O₁₂ |
Chemical formula | C₂₅H₂₄O₁₂ |
Hygroscopic | Hygroscopic |
Structure formula Image |
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Biological Information | |
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Purity | ≥95% by HPLC |
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R Phrase | R: 36/38 Irritating to eyes and skin. |
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Packaged under inert gas | Packaged under inert gas |
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