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Ru360

市场价：: 0.00

促销价：: ¥0.00

货号：557440-1SET

品牌：Millipore 密理博

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北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula
C₂H₂₆Cl₃N₈O₅Ru₂

Description
Overview	A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (K_d = 340 pM). Specifically blocks Ca²⁺ uptake into mitochondria in vitro (IC₅₀ = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca²⁺ transport processes involved in cardiac muscle contraction, even at micromolar levels.
Overview	Note: 1 set = 10 x 100 µg.
Catalogue Number	557440
Brand Family	Calbiochem®
Synonyms	(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃

References
References	Sanchez, J.A., et al. 2001. J. Physiol. 536, 387. Bassani, R.A., et al. 1998. Cell Calcium 23, 433. Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223. Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379. Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799. Ying, W.-L., et al. 1991. Biochemistry 30, 4949.

Product Information
ATP Competitive	N
Form	Green solid
Hill Formula	C₂H₂₆Cl₃N₈O₅Ru₂
Chemical formula	C₂H₂₆Cl₃N₈O₅Ru₂
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	Ca2+ uptake into mitochondria in vitro
Primary Target IC<sub>50</sub>	184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
Purity	≥97% by capillary electrophoresis

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Unstable in solution; reconstitute just prior to use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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