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| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₂₇H₂₁N₃O₅ | 97161-97-2 |
| Description | |
|---|---|
| Overview | A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297). |
| Catalogue Number | 420298 |
| Brand Family | Calbiochem® |
| Product Information | |
|---|---|
| CAS number | 97161-97-2 |
| ATP Competitive | Y |
| Form | White solid |
| Hill Formula | C₂₇H₂₁N₃O₅ |
| Chemical formula | C₂₇H₂₁N₃O₅ |
| Reversible | Y |
| Structure formula Image | |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
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| Safety Information according to GHS | |
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| RTECS | NZ0550000 |
| Safety Information |
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