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| Replacement Information |
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| Empirical Formula | CAS # |
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| C₁₇H₁₆N₂O₃ | 215543-92-3 |
| Description | |
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| Overview | A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available. |
| Catalogue Number | 572630 |
| Brand Family | Calbiochem® |
| Synonyms | 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone |
| References | |
|---|---|
| References | Mohammadi, M., et al. 1997. Science 276, 955. |
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| Cell permeable | Y |
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