NRG1 Isoform SMDF, Human, Recombinant - 炼石商城

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NRG1 Isoform SMDF, Human, Recombinant

市场价：: 0.00

促销价：: ¥0.00

货号：492027-25UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Purity
>95% by SDS-PAGE

Description
Overview	Recombinant, human neuregulin 1 (NRG1), isoform SMDF (sensory and motor neuron-derived factor), consisting of amino acids 1-263, 117-296, and 162-296, each fused at the C-terminus to a His•Tag^® sequence and expressed in S. frugiperda Sf21 cells using a baculovirus expression system. The neuregulin (also known as heregulin) family of cytokines is comprised of multiple secreted or membrane-bound isorforms that are produced from the single heregulin gene by alternative splicing and/or usage of different promoters. NRG1 isoform SMDF is a type III isoform with a C-terminal EGF-like domain that interacts with the erbB family of tyrosine kinase receptors. NRG1 isoform SMDF expression has been found to be restricted to the nervous system and is believed to play an important role in the development of the nervous system.
Catalogue Number	492027
Brand Family	Calbiochem®
Synonyms	Heregulin-1

References
References	Meyer, D. et al. 1997. Development 124, 3575. Yarden, Y. and D. Wen 1994. in Guidebook to Cytokinesand Their Receptors, N.A. Nicola, Ed., Oxford University Press, p. 146. Karey, K.P., et al. 1988. Cancer Res. 48, 4083.

Product Information
Form	Lyophilized
Formulation	Lyophilized from 0.2 µm filtered PBS, BSA.

Applications

Biological Information
Biological activity	ED₅₀ = 1-5 ng/ml as measured in a serum-free proliferation assay using MCF-7 human breast adenocarcinoma cells.
Purity	>95% by SDS-PAGE

Physicochemical Information
Contaminants	Endotoxin: ≤1.0 EU/µg protein

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstituion refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

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