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Qiagen 凯杰 Biosharp Omega

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Staurosporine, Streptomyces sp.

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号:569397-100UG

牌:Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula CAS #
C₂₈H₂₆N₄O₃ 62996-74-1

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              Description
              Overview A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein kinase A (IC50 = 7 nM), CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase C (IC50 = 700 pM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint. A 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569396) in DMSO is also available.
              Catalogue Number 569397
              Brand Family Calbiochem®
              Synonyms PKA Inhibitor II, MLCK Inhibitor I
              References
              References Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
              Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
              Bruno, S., et al. 1992. Cancer Res. 52, 470.
              Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
              Vitale, M.L., et al. 1992. Neuroscience 51, 463.
              Hoffman, R. and Newland, E.S. 1991. Cancer Chemother. Pharmacol. 28, 102.
              Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
              Product Information
              CAS number 62996-74-1
              ATP Competitive Y
              Form White to pale yellow solid
              Hill Formula C₂₈H₂₆N₄O₃
              Chemical formula C₂₈H₂₆N₄O₃
              Reversible Y
              Structure formula Image Structure formula Image
              Applications
              Biological Information
              Primary Target PKA
              Primary Target IC<sub>50</sub> 7 nM, 20 nM, 1.3 nM, 700 pM, and 8.5 nM against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
              Purity ≥99% by HPLC
              Physicochemical Information
              Cell permeable Y
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special Instructions Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

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