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InSolutionTM JAK Inhibitor I

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号:420097-500UG

牌:Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula CAS #
C₁₈H₁₆FN₃O 457081-03-7
Description
Catalogue Number 420097
Brand Family Calbiochem®
Synonyms 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
References
References Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
Product Information
CAS number 457081-03-7
ATP Competitive Y
Form Liquid
Formulation A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
Hill Formula C₁₈H₁₆FN₃O
Chemical formula C₁₈H₁₆FN₃O
Hygroscopic Hygroscopic
Reversible Y
Structure formula Image Structure formula Image
Applications
Application InSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).
Biological Information
Primary Target murine JAK1
Primary Target IC<sub>50</sub> 15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
Primary Target K<sub>i</sub> 5 nM against JAK3
Purity ≥98% by HPLC
Physicochemical Information
Cell permeable Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special Instructions Following initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

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