0
| Replacement Information |
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| Empirical Formula |
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| C₇₁H₈₁N₁₉O₁₈S₅ |
| Description | |
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| Overview | A cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells. |
| Catalogue Number | 567060 |
| Brand Family | Calbiochem® |
| Synonyms | NSC 285116, FOXM1 Inhibitor II |
| Product Information | |
|---|---|
| Form | White solid |
| Hill Formula | C₇₁H₈₁N₁₉O₁₈S₅ |
| Chemical formula | C₇₁H₈₁N₁₉O₁₈S₅ |
| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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