NF-KB SN50, CELL-PERMEABLE INHIBITOR PEPTIDE - 炼石商城

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NF-KB SN50, CELL-PERMEABLE INHIBITOR PEPTIDE

市场价：: 0.00

促销价：: ¥0.00

货号：481480-500UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

Description
Overview	Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
Catalogue Number	481480
Brand Family	Calbiochem®
Synonyms	AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

References
References	Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

Product Information
ATP Competitive	N
Declaration	Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₂₉H₂₃₀N₃₆O₂₉S
Chemical formula	C₁₂₉H₂₃₀N₃₆O₂₉S
Hygroscopic	Hygroscopic
Reversible	N
Sold on the basis of peptide content	Y

Applications

Biological Information
Primary Target	translocation of the NF-κB active complex into the nucleus
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Content	Y
Peptide Sequence	H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Packaging Information

Transport Information

Supplemental Information

Specifications

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