A component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
Catalogue Number
524644
Brand Family
Calbiochem®
Synonyms
PIP₂
References
References
Baukrowitz, T., et al. 1998. Science 282, 1141. Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138. Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181. Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403. Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852. Williamson, J.R. 1986. Hypertension 8, 140. Berridge, M.J., and Irvine, R.F. 1984. Nature312, 315.
Product Information
CAS number
383907-42-4
ATP Competitive
N
Form
White to off-white solid
Hill Formula
C₄₇H₈₂O₁₉P₃ · 3NH₄
Chemical formula
C₄₇H₈₂O₁₉P₃ · 3NH₄
Hygroscopic
Hygroscopic
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
Brain phospholipase D (PLD)
Purity
≥98% by TLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 36/37/38
Irritating to eyes, respiratory system and skin.
S Phrase
S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Irritant
Storage
≤ -70°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
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