Recombinant, human transforming growth factor-α expressed in E. coli. Plays an important role in cell-cell adhesion and cell growth and differentiation. Reported to play a role in the development of hormonal insensitivity in estrogen-receptor-positive breast cancers.
Catalogue Number
616430
Brand Family
Calbiochem®
Synonyms
Transforming Growth Factor-α
References
References
Nicholson, R.I., et al. 1994. Cancer Res. 54, 1684. Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA87, 3289. Massague, J. 1990. J. Biol. Chem.265, 21393. Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA84, 1258. Schreiber, A.B., et al. 1986. Science232, 1250. Tam, J.P. 1985. Science229, 673. Derynck, R., et al. 1984. Cell38, 327.
Product Information
CAS number
105186-99-0
Form
Lyophilized
Formulation
Lyophilized from 30% acetonitrile, 0.1% TFA.
Applications
Biological Information
Biological activity
ED₅₀= 0.1-0.4 ng/ml as measured by the ability to stimulate ³H-thymidine incorporation in the mouse fibroblast cell line Balb/3T3
Purity
≥97% by SDS-PAGE
Physicochemical Information
Contaminants
Endotoxin: ≤100 pg/µg TGF-α
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Standard Handling
Storage
≤ -70°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
Canadian export regulations
Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
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