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| Replacement Information |
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| Description | |
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| Overview | A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositiol 4,5-bisphosphate. May also block serotonin release, and stimulate the production of phospholipases C and D. Due to its ability to affect depolymerization of the cytoskeleton, toxin B has been shown to inhibit biphasic muscle contraction. Unlike Exoenzyme C3 (Cat. No. 341208), this toxin does not require assistance to permeabilize cells. |
| Catalogue Number | 616377 |
| Brand Family | Calbiochem® |
| Synonyms | Cytotoxin |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Lyophilized |
| Formulation | Lyophilized from 50 mM Tris, 50 mM NaCl, 0.1% trehalose, pH 7.5. |
| Reversible | N |
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| Physicochemical Information | |
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| Cell permeable | N |
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| Safety Information according to GHS | |
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| RTECS | XW5807300 |
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