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| Replacement Information |
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| Empirical Formula | CAS # |
|---|---|
| C₁₄H₁₂BrN₅ | 171179-06-9 |
| Description | |
|---|---|
| Overview | A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC50 = 8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH 3T3 cells. A 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513036) in DMSO is also available. |
| Catalogue Number | 513035 |
| Brand Family | Calbiochem® |
| Synonyms | 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine |
| References | |
|---|---|
| References | Cunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468. Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742. |
| Product Information | |
|---|---|
| CAS number | 171179-06-9 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₄H₁₂BrN₅ |
| Chemical formula | C₁₄H₁₂BrN₅ |
| Reversible | Y |
| Structure formula Image | |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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