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PD 145065

市场价：: 0.00

促销价：: ¥0.00

货号：513020-500UG

品牌：Millipore 密理博

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北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₅₂H₆₃N₇O₁₀ · 2Na	153049-49-1

Description
Overview	A highly potent but non-selective endothelin receptor antagonist [IC₅₀= 4 nM for the ET_A receptor (rabbit renal artery vascular smooth muscle cells); IC₅₀ = 15 nM for the ET_B receptor (rat cerebellum)].
Catalogue Number	513020
Brand Family	Calbiochem®

References
References	Han, H.K., et al. 1998. Life Sci. 63, 1599. Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482. Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201. Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154. Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).

Product Information
CAS number	153049-49-1
ATP Competitive	N
Form	White solid
Hill Formula	C₅₂H₆₃N₇O₁₀ · 2Na
Chemical formula	C₅₂H₆₃N₇O₁₀ · 2Na
Reversible	N

Applications

Biological Information
Primary Target	Endothelin receptor antagonist
Primary Target IC<sub>50</sub>	4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (rat cerebellum)
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	Ac-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.

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