Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Catalogue Number
582243
Brand Family
Calbiochem®
References
References
Montecucco, C., et al. 1994. FEBS Lett. 346, 92. Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Product Information
ATP Competitive
N
Form
Lyophilized
Reversible
N
Applications
Biological Information
Biological activity
Binds GT1b ganglioside in a hemagglutination assay
Primary Target
Tetanus toxin is one of the deadliest toxins known
Purity
Single band by SDS-PAGE
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
XW5807000
Safety Information
R Phrase
R: 26/27/28
Very toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 45
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Canadian export regulations
Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
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