Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.
Catalogue Number
580551
Brand Family
Calbiochem®
References
References
McCluskey, A., et al. 2002. J. Med. Chem.45, 1151. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun.287, 328. Kikuchi, K., et al. 1999. Int. J. Mol. Med.4, 395. Sheppeck, J.E., et al. 1997. J. Org. Chem.62, 387. Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett.6, 3. Gong, M.C., et al. 1992. J. Biol. Chem.267, 14662. Suganuma, M., et al. 1992. Toxicon30, 873. MacKintosh, C. and Klumpp, S. 1990. FEBS Lett.277, 137. Magae, J., et al. 1989. J. Antibiot.42, 1290.
Product Information
CAS number
109946-35-2
ATP Competitive
N
Form
Lyophilized thin film
Hill Formula
C₄₁H₆₆O₁₃
Chemical formula
C₄₁H₆₆O₁₃
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
PP1
Primary Target IC<sub>50</sub>
1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively
Purity
≥97% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
WX1000000
Safety Information
R Phrase
R: 26/27/28
Very toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 22-36/37/39-45
Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Protect from Light
Protect from light
Protect from Moisture
Protect from moisture
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
From Catalog: Desc. Field- removed ". . .and useful for studies involving protein phosphorylation" - removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase
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