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| Replacement Information |
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| Empirical Formula |
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| C₁₅₀H₂₂₇N₅₇O₃₂S₂ |
| Description | |
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| Overview | The p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system. |
| Catalogue Number | 506181 |
| Brand Family | Calbiochem® |
| Synonyms | TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic |
| References | |
|---|---|
| References | Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461. Schwarze, S.R., et al. 1999. Science 285, 1569. |
| Biological Information | |
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| Primary Target | Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH disulfide bond (12-26) |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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