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InSolutionTM OM99-2

市场价：: 0.00

促销价：: ¥0.00

货号：496000-250UG

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₄₁H₆₄N₈O₁₄	314266-76-7

Description
Overview	An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (K_i = 1.6 nM, recombinant memapsin 2; K_i = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (K_i = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
Catalogue Number	496000
Brand Family	Calbiochem®
Synonyms	EVNLΨAAEF

References
References	Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

Product Information
CAS number	314266-76-7
ATP Competitive	N
Form	Liquid
Formulation	A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Hill Formula	C₄₁H₆₄N₈O₁₄
Chemical formula	C₄₁H₆₄N₈O₁₄
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	human brain memapsin 2
Primary Target K<sub>i</sub>	1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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