Replacement Information |
---|
Empirical Formula | CAS # |
---|---|
C₄₄H₆₈O₁₃ | 78111-17-8 |
Description | |
---|---|
Overview | An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available. |
Catalogue Number | 495604 |
Brand Family | Calbiochem® |
Synonyms | OA |
Product Information | |
---|---|
CAS number | 78111-17-8 |
ATP Competitive | N |
Form | Colorless glassy solid |
Hill Formula | C₄₄H₆₈O₁₃ |
Chemical formula | C₄₄H₆₈O₁₃ |
Reversible | N |
Structure formula Image |
Applications |
---|
Biological Information | |
---|---|
Primary Target | Protein phosphatase |
Primary Target IC<sub>50</sub> | 10-15 nM and 0.1 nM against protein phosphatase 1 and protein phosphatase 2A, respectively |
Purity | ≥95% by HPLC |
Physicochemical Information | |
---|---|
Cell permeable | N |
Dimensions |
---|
Materials Information |
---|
Toxicological Information |
---|
Safety Information according to GHS | |
---|---|
RTECS | AA8227800 |
Product Usage Statements |
---|
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Transport Information |
---|
Supplemental Information |
---|
Specifications |
---|
温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知,且每位咨询者购买情况、提问时间等不同,为此以下回复仅对提问者3天内有效,其他网友仅供参考!若由此给您带来不便请多多谅解,谢谢!
服务热线
0771-3293894