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| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₂₅H₄₂BN₃O₆ | 179324-22-2 |
| Description | |
|---|---|
| Overview | A boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 30 pM vs. 4 nM for MG-132). |
| Catalogue Number | 539163 |
| Brand Family | Calbiochem® |
| Synonyms | MG-262, Z-LLL-B(OH)₂ |
| References | |
|---|---|
| References | Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333. Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103. |
| Product Information | |
|---|---|
| CAS number | 179324-22-2 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₅H₄₂BN₃O₆ |
| Chemical formula | C₂₅H₄₂BN₃O₆ |
| Reversible | Y |
| Biological Information | |
|---|---|
| Primary Target | proteasome |
| Primary Target K<sub>i</sub> | 30 pM against proteasome |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Peptide Sequence | Z-Leu-Leu-Leu-B(OH)₂ |
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