Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
Catalogue Number
679101
Brand Family
Calbiochem®
Synonyms
1,25-(OH)₂-D₃, Calcitriol
References
References
Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412. Hannun, Y.A. 1994. J. Biol. Chem.269, 3125. Mathieu, C., et al. 1994. Diabetologica37, 552. Thomasset, M. 1994. Pathol. Biol. 42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem.266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun.176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun.176, 1189. Wakasugi, M., et al. 1991. Prostaglandins42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun.166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem.264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem.52, 411.
Product Information
CAS number
32222-06-3
Form
Solid
Hill Formula
C₂₇H₄₄O₃
Chemical formula
C₂₇H₄₄O₃
Structure formula Image
Applications
Biological Information
Purity
≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
FZ4645000
Safety Information
R Phrase
R: 26/27/28-63
Very toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child.
S Phrase
S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Blue Ice Only
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.