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VEGFR Tyrosine Kinase Inhibitor IV

市场价：: 0.00

促销价：: ¥0.00

货号：676483-500UG

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₂₂H₁₉ClN₄O₅ • H₂O	475108-18-0

Description
Overview	A cell-permeable quinoline-urea compound that potently inhibits the kinase activity of VEGFR (IC₅₀ = 30, 6.5, and 15 nM for VEGFR-1,-2,and -3, respectively), EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie-2 (IC₅₀ = 24, 40, 49, 78, and 78 nM, respectively). It exhibits little or no activity towards a panel of 15 other tyrosine kinases, including FGFR, IR, and IGFR, in cell-free kinase assays, while showing more than 7-fold higher potency in inhibiting ligand-induced phosphorylation of VEGFR-1/2/3 vs. c-Kit, PDGFR-β, Flt3, FGFR1, and c-Met in cell-based assays. Shown to be orally available and suppress tumor angiogenesis and growth in rats in vivo.
Catalogue Number	676483
Brand Family	Calbiochem®
Synonyms	Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor IV, N-(2-Chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-Nʹ-(5-methyl-3-isoxazolyl)urea, PDGFR Tyrosine Kinase Inhibitor XII, VEGFR2 Kinase Inhibitor XXI, VEGFR1 Kinase Inhibitor V, VEGFR3 Kinase Inhibitor V

References
References	Nakamura, K., et al. 2006. Cancer Res. 66, 9134.

Product Information
CAS number	475108-18-0
ATP Competitive	N
Form	Pink solid
Hill Formula	C₂₂H₁₉ClN₄O₅ • H₂O
Chemical formula	C₂₂H₁₉ClN₄O₅ • H₂O
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	VEGFR
Primary Target IC<sub>50</sub>	30, 6.5, and 15 nM for VEGFR-1,-2, and -3, respectively; 24, 40, 49, 78, and 78 nM for EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie-2, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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