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| Replacement Information |
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| Empirical Formula | CAS # |
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| C₂₀H₂₅N₃O | 82-89-3 |
| Description | |
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| Overview | A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 µM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 µM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 µM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.). |
| Catalogue Number | 529685 |
| Brand Family | Calbiochem® |
| Synonyms | Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147 |
| Product Information | |
|---|---|
| CAS number | 82-89-3 |
| Form | Dark red solid |
| Hill Formula | C₂₀H₂₅N₃O |
| Chemical formula | C₂₀H₂₅N₃O |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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