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Melittin

市场价：: 0.00

促销价：: ¥0.00

货号：444605-250UG

品牌：Millipore 密理博

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北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₃₁H₂₂₉N₃₉O₃₁	37231-28-0

Description
Overview	A 26-residue polypeptide from bee venom that binds calmodulin in a Ca²⁺-dependent manner. A stimulator of G_iα and G₁₁α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Activates phospholipase A₂ and inhibits protein kinase C (IC₅₀ = 5-7 µM) by binding to the catalytic domain in a Mg²⁺-ATP sensitive manner. Has also been used for affinity purification of several Ca²⁺-binding proteins.
Catalogue Number	444605
Brand Family	Calbiochem®

References
References	Fukushima, N., et al. 1998. Peptides 19, 811. Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425. Baudier, J., et al. 1987. Biochemistry 26, 2886. Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.

Product Information
CAS number	37231-28-0
ATP Competitive	N
Form	Lyophilized
Hill Formula	C₁₃₁H₂₂₉N₃₉O₃₁
Chemical formula	C₁₃₁H₂₂₉N₃₉O₃₁
Reversible	N
Sold on the basis of peptide content	Y

Applications

Biological Information
Primary Target	PKC
Primary Target IC<sub>50</sub>	5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C
Purity	>97% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	OS3960000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

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