Lactacystin, Synthetic

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货号：426100-200UG

品牌：Millipore 密理博

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₅H₂₄N₂O₇S	1258004-00-0

Description
Overview	An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC₅₀ = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G₁ phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC₅₀ = 10 µM).
Catalogue Number	426100
Brand Family	Calbiochem®
Synonyms	Proteasome Inhibitor VI

References
References	Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273. Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800. Fenteany, G., et al. 1995. Science 268, 726. Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070. Jensen, T.J., et al. 1995. Cell 83, 129. Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344. Mori, S., et al. 1995. J. Biol. Chem. 270, 29447. Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291. Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358. Omura, S., et al. 1991. J. Antibiot. 44, 117.

References

Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
Fenteany, G., et al. 1995. Science 268, 726.
Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
Jensen, T.J., et al. 1995. Cell 83, 129.
Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
Omura, S., et al. 1991. J. Antibiot. 44, 117.

Product Information
CAS number	1258004-00-0
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₂₄N₂O₇S
Chemical formula	C₁₅H₂₄N₂O₇S
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	20S proteasome (MCP; multicatalytic proteinase complex)
Primary Target IC<sub>50</sub>	500 nM against 20S proteasome; 10 µM against NF-κB activation
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.