Dkk-1, Rat, Recombinant

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Dkk-1, Rat, Recombinant

市场价：: 0.00

促销价：: ¥0.00

货号：371208-10UG

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Purity
≥95% by SDS-PAGE

Description
Overview	Recombinant, rat Dickkopf related protein-1 (Dkk-1), consisting of amino acids 23-270, fused at the C-terminus to a His•Tag^® sequence, and expressed in NS0-derived mouse myeloma cells. The balance between Wnt signaling and Dkk-1 inhibition is essential for bone formation and homeostasis.
Catalogue Number	371208
Brand Family	Calbiochem®

References
References	Li, J. et al. 2006. Bone 36, 754. Morvan, F. et al. 2006. J. Bone Miner. Res. 21, 934. Niehrs, C. 2006. Oncogene 25, 7469. Verani, R. et al. 2006. J. Neurochem. 101, 242. Cappuccio, I. et al. 2005. J. Neurosci. 25, 2647. Kemp, C. et al. 2005. Dev. Dyn. 233, 1064. Adamska, M. et al. 2004. Dev. Biol. 272, 134. Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582. Mao, B. et al. 2002. Nature 417, 664. Mao, B. et al. 2001. Nature 411, 321. Krupnik, V.E., et al. 1999. Gene 238, 301.

References

Li, J. et al. 2006. Bone 36, 754.
Morvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
Niehrs, C. 2006. Oncogene 25, 7469.
Verani, R. et al. 2006. J. Neurochem. 101, 242.
Cappuccio, I. et al. 2005. J. Neurosci. 25, 2647.
Kemp, C. et al. 2005. Dev. Dyn. 233, 1064.
Adamska, M. et al. 2004. Dev. Biol. 272, 134.
Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
Mao, B. et al. 2002. Nature 417, 664.
Mao, B. et al. 2001. Nature 411, 321.
Krupnik, V.E., et al. 1999. Gene 238, 301.

Product Information
Form	Lyophilized
Formulation	Lyophilized from 0.2 µm filtered PBS, BSA.

Applications

Biological Information
Biological activity	ND₅₀ = 0.1-0.5 µg/ml as measured by inhibition of Wnt-3a-induced (10 ng/ml rmWnt-3a) alkaline phosphatase production by proliferation of MC3T3-E1 mouse osteoblastic cells.
Purity	≥95% by SDS-PAGE

Physicochemical Information
Contaminants	Endotoxin: ≤1.0 EU/µg protein

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.