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| Replacement Information |
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| Description | |
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| Overview | Recombinant, human procathepsin V (amino acids 18-334) fused at the N-terminus to a CD33 signal sequence (amino acids 1-16) and at the C-terminus to a His•Tag® sequence and expressed in NSO cells. Cat V is predominantly expressed in normal thymus, testis, and corneal epithelium. It is involved in the invariant chain degradation in thymic epithelial cells and its overexpression has been detected in myasthenia gravis. Abnormally wide spread expressions in mammary gland and colon have also been reported in breast and colonrectal carcinomas. Although it shows high amino acid identity with cathepsin L (Cat. No. 219382), these two cathepsins have very different tissue distribution and substrate specificity. As a result of glycosylation, this recombinant enzyme migrates ~40 kDa on SDS-PAGE under either reducing or non-reducing conditions. Requires activation prior to use. |
| Catalogue Number | 219467 |
| Brand Family | Calbiochem® |
| Synonyms | Cathepsin L2, Cathepsin U |
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| Biological Information | |
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| Purity | ≥95% by SDS-PAGE |
| Specific Activity | ≥300 units/µg |
| Concentration Label | Please refer to vial label for lot-specific concentration |
| Physicochemical Information | |
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| Contaminants | Endotoxins: ≤1.0 EU/µg Cathepsin V |
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