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Qiagen 凯杰 Biosharp Omega

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Guanosine 3?,5?-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt

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号:370674-5UMOL

牌:Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula
C₁₀H₁₀BrN₅O₆PS · Na
Description
Overview A potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; Ki = 4 µM). Acts as a cyclic nucleotide-gated channel agonist (EC50 = 173.5 µM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 µmol = 2.31 mg.
Catalogue Number 370674
Brand Family Calbiochem®
Synonyms Rp-8-Br-cGMPS, Na, PKG Inhibitor II
References
References Wei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
Zhuo, M., et al. 1994. Nature 368, 635.
Product Information
ATP Competitive N
Declaration Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
Form Lyophilized
Hill Formula C₁₀H₁₀BrN₅O₆PS · Na
Chemical formula C₁₀H₁₀BrN₅O₆PS · Na
Hygroscopic Hygroscopic
Reversible N
Structure formula Image Structure formula Image
Applications
Biological Information
Primary Target PKG
Primary Target K<sub>i</sub> 4 µM against protein kinase G (PKG)
Purity ≥99% by HPLC
Physicochemical Information
Cell permeable Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

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