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Gö 6983

市场价：: 0.00

促销价：: ¥0.00

货号：365251-500UG

品牌：Millipore 密理博

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北京朝阳

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₂₆H₂₆N₄O₃	133053-19-7

Description
Overview	A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC₅₀ = 7 nM for PKC_α and PKC_β; 6 nM for PKC_γ; 10 nM for PKC_δ; and 60 nM for PKC_ζ). Gö 6983 does not effectively inhibit PKC_µ (IC₅₀ = 20 µM) and can thus be used to differentiate PKC_µfrom other PKC isozymes.
Catalogue Number	365251
Brand Family	Calbiochem®
Synonyms	2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983

References
References	Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805. Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

Product Information
CAS number	133053-19-7
ATP Competitive	Y
Form	Orange red solid
Hill Formula	C₂₆H₂₆N₄O₃
Chemical formula	C₂₆H₂₆N₄O₃
Reversible	Y
Structure formula Image

Applications
Application	Gö 6983, CAS 133053-19-7, is a potent, cell-permeable, reversible, and ATP-competitive inhibitor of several PKC isozymes (IC50 = 7 nM for PKCα & β; 6 nM for PKCγ; 10 nM for PKCδ; & 60 nM for PKCζ).

Biological Information
Primary Target	PKCα and PKCβ
Primary Target IC<sub>50</sub>	7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

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