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| Replacement Information |
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| Empirical Formula | CAS # |
|---|---|
| C₂₄H₁₈N₄O | 136194-77-9 |
| Description | |
|---|---|
| Overview | A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available. |
| Catalogue Number | 365250 |
| Brand Family | Calbiochem® |
| Synonyms | Go 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole |
| Product Information | |
|---|---|
| CAS number | 136194-77-9 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₂₄H₁₈N₄O |
| Chemical formula | C₂₄H₁₈N₄O |
| Reversible | Y |
| Structure formula Image | |
| Applications |
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| Biological Information | |
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| Primary Target | PKC |
| Primary Target IC<sub>50</sub> | 7.9 nM against rat brain PKC; 2.3 nM, 6.2 nM against Ca2+-dependent PKC α-isozyme and PKCβI, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
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