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Qiagen 凯杰 Biosharp Omega

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PP2A Inhibitor II, GST-Fusio 1PC x 250NG

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号:539620-250NG

牌:Millipore 密理博

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Description
Overview

This product has been discontinued.



Recombinant, human PP2AI I2 fused to GST and expressed in E. coli. Inhibits protein phosphatase 2A (PP2A) potently with Ki ~ 25-30 nM with myelin basic protein, histone H1, and other substrates of PP2A but not with casein as a substrate. Stimulates PP1. Prevents inhibition of E-Cdk-2 by p21Cip1. Associates with B cyclin. Regulates histone binding to DNA, transcriptional activity and chromatin condensation. Undergoes phosphorylation in cells. Highly expressed in some cancers. Associates with HRX leukemia-associated fusion proteins. Occurs as fusion protein in acute undifferentiated leukemia. Does not inhibit PP1, PP2B, PP2C, or pyruvate dehydrogenase.

Catalogue Number 539620
Brand Family Calbiochem®
Synonyms Protein Phosphatase 2A Inhibitor II, I₂PP2A
References
References Li, M., et al. 1996. Biochemistry 35, 6998.
Li, M., et al. 1995. Biochemistry 34, 1988.
Product Information
ATP Competitive N
Form Liquid
Formulation In 50 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 1 mM EDTA, 0.1 mM PMSF, 10% glycerol, pH 7.4.
Reversible N
Applications
Biological Information
Primary Target PP2A
Primary Target K<sub>i</sub> ~ 25-30 nM
Purity ≥90% by SDS-PAGE
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeable N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special Instructions Following initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

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