A epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
Caution! Product contains volatile liquid. Keep product cold at all times.
Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci.24, 323. Filep, J.G., et al. 2002. Adv. Exp. Med. Biol.507, 223. Titos, E., et al. 1999. Am. J. Physiol.277, C870. Gronert, K., et al. 1998. J. Exp. Med.187, 1285. Maddox, J.F., et al. 1997. J. Biol. Chem.272, 6972. Claria, J., et al. 1996. Mol. Med.2, 583. Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA92, 9475. Serhan, C.N., et al. 1995. Biochemistry34, 14609.
Product Information
CAS number
171030-11-8
ATP Competitive
N
Form
Liquid
Formulation
In Ethanol.
Hill Formula
C₂₀H₃₂O₅
Chemical formula
C₂₀H₃₂O₅
Hygroscopic
Hygroscopic
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
Exhibits anti-inflammatory properties
Purity
≥98% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Flammable
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw aliquot and freeze (-70°C).
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