Potent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.
Caution! Product contains volatile liquid. Keep product cold at all times.
McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566. Soyombo, O., et al. 1994. Allergy 49, 230. Flore, S., et al. 1992. J. Biol. Chem.267, 16168. Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA86, 3438.
Product Information
CAS number
89663-86-5
ATP Competitive
N
Form
Liquid
Formulation
In Ethanol.
Hill Formula
C₂₀H₃₂O₅
Chemical formula
C₂₀H₃₂O₅
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
Potent inhibitor of cytotoxic activity of human natural killer cells
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 11-36/37/38
Highly flammable. Irritating to eyes, respiratory system and skin.
S Phrase
S: 16-26-36-7
Keep away from sources of ignition - No Smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. Keep container tightly closed.
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Flammable
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C).
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