Implicated in renal vasoconstriction associated with sepsis. Also plays a role in bronchioconstriction. Produced by conjugation of LTA4 with reduced glutathione. Reported to be a tight binding inhibitor of microsomal glutathione transferase-1. Has been implicated in pathophysiology of asthma.
Bannenberg, G., et al. 1999. J. Biol. Chem. 274, 1994. Shimizu, T., et al. 1994. Pediatr. Pulmonol. 18, 129.
Product Information
CAS number
72025-60-6
ATP Competitive
N
Form
Liquid
Formulation
In MeOH:NH₄OAc buffer (65:35), pH 5.6.
Hill Formula
C₃₀H₄₇N₃O₉S
Chemical formula
C₃₀H₄₇N₃O₉S
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
Microsomal glutathione transferase-1
Purity
≥98% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
MB9143500
Safety Information
R Phrase
R: 11-23/24/25-39/23/24/25
Highly flammable. Toxic by inhalation, in contact with skin and if swallowed. Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
S Phrase
S: 16-7-36/37-45
Keep away from sources of ignition - No Smoking. Keep container tightly closed. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Flammable
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquor and freeze (-70°C).
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