Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema and asthma.
Kendall, A.P., et al. 1995. Anesthesia 50, 590. Dokter, W.H., et al. 1994. Leukemia 8, 1181. Jedlitschky, G., et al. 1991. J. Biol. Chem.266, 24763.
Product Information
CAS number
71160-24-2
ATP Competitive
N
Form
Clear oil
Formulation
In Ethanol.
Hill Formula
C₂₀H₃₂O₄
Chemical formula
C₂₀H₃₂O₄
Reversible
N
Structure formula Image
Applications
Biological Information
Primary Target
Polymorphonuclear leukocytes
Purity
>98% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 11
Highly flammable.
S Phrase
S: 16-7
Keep away from sources of ignition - No Smoking. Keep container tightly closed.
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Flammable
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C).
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