InSolutionTM Leptomycin B, Streptomyces sp.

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InSolutionTM Leptomycin B, Streptomyces sp.

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货号：431050-5UG

品牌：Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₃₃H₄₈O₆	87081-35-4

Description
Overview	An antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. It is about twice as potent as Leptomycin A (Cat. No. 431051) in inhibiting nucleocytoplasmic translocation of Rev, blocks the Rev-dependent export of mRNA into cytoplasm, and suppresses HIV-1 replication in primary human monocytes (IC₅₀ = 600 pM). In addition, LMB effectively induces the accumulation of p53 in the nucleus of normal fibroblasts as well as protects p53 from Mdm2-mediated ubiquitination and degradation.
Overview	Caution! Product contains volatile liquid. Keep product cold at all times.
Catalogue Number	431050
Brand Family	Calbiochem®
Synonyms	LMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I

References
References	Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78. Menendez, S., et al. 2003. Br. J. Cancer 88, 636. Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66. Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112. Lain, S., et al. 1999. Exp. Cell Res. 248, 457. Wolff, B., et al. 1997. Chem. Biol. 4, 139. Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150. Komiyama, K., et al. 1985. J. Antibiot. 38, 427.

References

Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
Wolff, B., et al. 1997. Chem. Biol. 4, 139.
Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
Komiyama, K., et al. 1985. J. Antibiot. 38, 427.

Product Information
CAS number	87081-35-4
ATP Competitive	N
Form	Liquid
Formulation	Supplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol
Hill Formula	C₃₃H₄₈O₆
Chemical formula	C₃₃H₄₈O₆
Reversible	N
Structure formula Image

Applications
Application	InSolution™ Leptomycin B, Streptomyces sp., CAS 87081-35-4, is a 20 µg/ml solution in ethanol. An antifungal agent that blocks nuclear export by impairing the function of nuclear export factor CRM1.

Biological Information
Primary Target	HIV-1 replication in primary human monocytes
Primary Target IC<sub>50</sub>	600 pM in suppressing HIV-1 replication in primary human monocytes
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Flammable
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	≤ -70°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and freeze (-70°C).