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Chk2 Inhibitor

市场价：: 0.00

促销价：: ¥0.00

货号：220485-500UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₅H₁₃N₅O₂	724708-21-8

Description
Overview	A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC₅₀ = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC₅₀ = 89 nM, 237 nM, 1.352 µM, 2.539 µM, 3.381 µM, and > 10.0 µM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC₅₀ = 3.55 µM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 µM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI₅₀ = 1.73 µM).
Catalogue Number	220485
Brand Family	Calbiochem®
Synonyms	5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidine)-3,4,5,10-2H-azepino[3,4-b]indol-1-one, Chk1 Inhibitor II, Chk2 Inhibitor I

References
References	Sharma, V., and Tepe, J.J. 2004. Bioorg. Med. Chem. Lett. 14, 4319. Sharma, V., et al. 2004. J. Med. Chem. 47, 3700.

Product Information
CAS number	724708-21-8
ATP Competitive	Y
Declaration	Sold under license from Michigan State University.
Form	Pale yellow solid
Hill Formula	C₁₅H₁₃N₅O₂
Chemical formula	C₁₅H₁₃N₅O₂
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image

Applications

Biological Information
Primary Target	Chk2
Primary Target IC<sub>50</sub>	8 nM against Chk2
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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