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MMP-2/MMP-9 Inhibitor V

市场价：: 0.00

促销价：: ¥0.00

货号：444285-500UG

品牌：Millipore 密理博

配送至：

北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₆H₁₇NO₅S₃	869577-53-7

Description
Overview	A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (K_i = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (K_i = 3.6 µM, 295 µM, and > 25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and > 25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
Catalogue Number	444285
Brand Family	Calbiochem®
Synonyms	(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS

References
References	Ikejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.

Product Information
CAS number	869577-53-7
ATP Competitive	N
Form	White solid
Hill Formula	C₁₆H₁₇NO₅S₃
Chemical formula	C₁₆H₁₇NO₅S₃
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	MMP-2
Primary Target K<sub>i</sub>	16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively
Purity	≥85% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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