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MMP-2/MMP-9 Inhibitor IV

市场价：: 0.00

促销价：: ¥0.00

货号：444274-500UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₁₅H₁₄O₃S₂	292605-14-2

Description
Overview	A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM), and MMP-9 (K_i = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.
Catalogue Number	444274
Brand Family	Calbiochem®
Synonyms	SB-3CT

References
References	Krüger, A., et al. 2005. Cancer Res. 65, 3523. Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125. Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.

Product Information
CAS number	292605-14-2
ATP Competitive	N
Declaration	Sold under license of U.S. Patent 6,703,415.
Form	Off-white solid
Hill Formula	C₁₅H₁₄O₃S₂
Chemical formula	C₁₅H₁₄O₃S₂
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	MMP-2
Primary Target K<sub>i</sub>	13.9 nM
Purity	≥ 95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

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