Histone Deacetylase 8, His•Tag®, Human Recombinant, S. frugiperda - 炼石商城

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Histone Deacetylase 8, His•Tag®, Human Recombinant, S. frugiperda

市场价：: 0.00

促销价：: ¥0.00

货号：382184-50UG

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Description
Overview	Full length, recombinant, human histone deacetylase 8 (HDAC8) fused to at the C-terminus to a His•Tag^® sequence at and expressed in S. frugiperda insect cells using a baculovirus expression system. HDAC8 phosphorylated in vivo by PKA results in decreased activity, which leads to the hyperacetylation of histones H3 and H4. HDAC8 may play a role in one of the most frequent types of acute myeloid leukemia (AML). The active deacetylase is useful in the study of HDAC8 regulation and for inhibitor screening.
Catalogue Number	382184
Brand Family	Calbiochem®
Synonyms	HDAC8, Human, Recombinant

References
References	Waltregny, D., et al. 2005. FASEB J. 19, 966. Buggy, J.J., et al. 2000. Biochem J. 350, 199

Product Information
Unit of Definition	One unit is defined as the the amount of enzyme required to deacetylate 1 picomol fluorescent peptide substrate [Arg-His-Lys(Ac)-Lys(Ac)] per min at 30°C.
Form	Liquid
Formulation	In 138 mM NaCl, 25 mM Tris-HCl, 10% glycerol, 0.05% TWEEN^®-20 detergent, pH 8.0.

Applications
Application	Histone Deacetylase 8, His•Tag®, Human Recombinant, S. frugiperda, is a full length HDAC8 fused to His-Tag at the C-terminus. Useful in the study of HDAC8 regulation and for inhibitor screening.

Biological Information
Purity	≥90% by SDS-PAGE
Specific Activity	≥10 units/µg protein
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

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