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Qiagen 凯杰 Biosharp Omega

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PKC? Inhibitor

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号:539654-500UG

牌:Millipore 密理博

账期 货到付款

EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula CAS #
C₂₄H₂₁N₅O₂ 257879-35-9
Description
Overview An anilino-monoindolylmaleimide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI) and displays greater selectivity over PKCα, γ,& ε (IC50 = 331 nM, > 1 µM, and 2.8 µM, respectively).
Catalogue Number 539654
Brand Family Calbiochem®
Synonyms 3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
References
References Tanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
Product Information
CAS number 257879-35-9
ATP Competitive Y
Form Orange solid
Hill Formula C₂₄H₂₁N₅O₂
Chemical formula C₂₄H₂₁N₅O₂
Reversible Y
Structure formula Image Structure formula Image
Applications
Biological Information
Primary Target PKCβII, βI
Primary Target IC<sub>50</sub> 5 nM, 21 nM for human PKCβII and βI
Purity ≥90% by HPLC
Physicochemical Information
Cell permeable Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

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