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首页克隆与表达Millipore 密理博>

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货号：539644-500UG

品牌：Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₂₈H₂₆N₄O₄	112953-11-4

Description
Overview	A cell-permeable Staurosporine (Cat. No. 569397) derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases (IC₅₀ = 29 nM, 34 nM, 30 nM, 590 nM and 530 nM for PKCα, PKCβ, PKCγ, PKCδ and PKCε; IC₅₀ = 7 nM, 27 nM, 50 nM, 50 nM, 150 nM and 1.04 µM for Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2; IC₅₀ = 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 µM for PDK1, lck, MAPKAP kinase-2, Akt, GSK-3β and PKA, respectively). At higher concentrations (> 15 µM), affects the activities of Src, PIM-1, CKII, DNA-PK, ErK1, ILK-1 and MAPKK1). Reported to suppress thymidylate synthase expression, induce apoptosis with caspase activation, and sensitize tumor cells to a range of DNA-damaging agents.
Catalogue Number	539644
Brand Family	Calbiochem®
Synonyms	7-Hydroxystaurosporine, Staurosporine, 7β-Hydroxy, Streptomyces sp., Chk1 Inhibitor VI, Chk2 Inhibitor V

References
References	Reinhardt, H.C., et al. 2007. Cancer Cell 11, 175. Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221. Sato, S., et al. 2002. Oncogene 21, 1727. Patel, V., et al. 2002. Clin. Cancer Res. 8, 3549. Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251. Busby, E.C., et al. 2000. Cancer Res. 60, 2108. Hsueh, C.T., et al. 1998. Clin. Cancer Res. 4, 2201. Akiyama, T., et al. 1997. Cancer Res. 57, 1495. Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207. Takahashi, I., et al. 1987, J. Antibiot. 40, 1782.

References

Reinhardt, H.C., et al. 2007. Cancer Cell 11, 175.
Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
Sato, S., et al. 2002. Oncogene 21, 1727.
Patel, V., et al. 2002. Clin. Cancer Res. 8, 3549.
Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
Busby, E.C., et al. 2000. Cancer Res. 60, 2108.
Hsueh, C.T., et al. 1998. Clin. Cancer Res. 4, 2201.
Akiyama, T., et al. 1997. Cancer Res. 57, 1495.
Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207.
Takahashi, I., et al. 1987, J. Antibiot. 40, 1782.

Product Information
CAS number	112953-11-4
ATP Competitive	Y
Form	Tan solid
Hill Formula	C₂₈H₂₆N₄O₄
Chemical formula	C₂₈H₂₆N₄O₄
Reversible	Y
Structure formula Image

Applications

Biological Information
Primary Target	PKCα, PKCβ, PKCγ, PKCδ PKCε, Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2, PDK1, lck, MAPKAP kinase-2, Akt, GSK-3β and PKA
Primary Target IC<sub>50</sub>	IC50 = 29 nM, 34 nM, 30 nM, 590 nM, 530 nM, 7 nM, 27 nM, 50 nM, 50 nM, 150 nM, 1.04 µM, 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 µM, respectively for primary targets in the order listed
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.