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| Replacement Information |
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| Empirical Formula |
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| C₃₀H₄₃FN₄O₁₁ |
| Description | |
|---|---|
| Overview | A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available. |
| Catalogue Number | 218759 |
| Brand Family | Calbiochem® |
| Synonyms | Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | White to yellow powder |
| Hill Formula | C₃₀H₄₃FN₄O₁₁ |
| Chemical formula | C₃₀H₄₃FN₄O₁₁ |
| Reversible | N |
| Applications | |
|---|---|
| Application | Caspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. |
| Biological Information | |
|---|---|
| Primary Target | caspase-8 |
| Purity | single spot by TLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F* |
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