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Apamin, Bee Venom

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号:178270-500UG

牌:Millipore 密理博

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Replacement Information

重要规格表

Empirical Formula CAS #
C₇₉H₁₃₁N₃₁O₂₄S₄ 24345-16-2
Description
Overview Polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.
Catalogue Number 178270
Brand Family Calbiochem®
Synonyms CNCKAPETALCARRCQQH-NH₂
References
References Mourre, C., et al. 1997. Brain Res. 778, 405.
Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
Wang, X., et al. 1994. Brain Res. 662, 83.
Product Information
CAS number 24345-16-2
ATP Competitive N
Form White solid with dark tan cast
Hill Formula C₇₉H₁₃₁N₃₁O₂₄S₄
Chemical formula C₇₉H₁₃₁N₃₁O₂₄S₄
Hygroscopic Hygroscopic
Reversible N
Applications
Biological Information
Primary Target AHP-type Ca2+-activated K+ channel
Purity ≥98% by HPLC
Physicochemical Information
Cell permeable N
Peptide Sequence H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS CD6899900
Safety Information
R Phrase R: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S Phrase S: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

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