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| Replacement Information |
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| Empirical Formula |
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| C₆₄H₁₁₆N₂₂O₁₉ |
| Description | |
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| Overview | Non-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM). It is about 50 times more potent than [Ala286]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca2+-induced insulin secretion from electropermeabilized islets. |
| Catalogue Number | 189480 |
| Brand Family | Calbiochem® |
| Synonyms | AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL |
| References | |
|---|---|
| References | Bhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655. Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | White solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₆₄H₁₁₆N₂₂O₁₉ |
| Chemical formula | C₆₄H₁₁₆N₂₂O₁₉ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Applications |
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| Biological Information | |
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| Primary Target | Cam Kinase-2 |
| Primary Target IC<sub>50</sub> | 40 nM against calmodulin-dependent protein kinase II |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Peptide Sequence | H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH |
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