Bafilomycin A1, Streptomyces griseus

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Bafilomycin A1, Streptomyces griseus

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货号：196000-1SET

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

重要规格表

Empirical Formula	CAS #
C₃₅H₅₈O₉	88899-55-2

Description
Overview	A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
Overview	Note: 1 set = 3 x 10 µg
Catalogue Number	196000
Brand Family	Calbiochem®

References
References	Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

References

Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

Product Information
CAS number	88899-55-2
Form	White solid
Hill Formula	C₃₅H₅₈O₉
Chemical formula	C₃₅H₅₈O₉
Structure formula Image

Applications

Biological Information
Primary Target	vacuolar type H⁺ ATPase
Primary Target IC<sub>50</sub>	500 pM
Purity	≥90% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.