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Empirical Formula | CAS # |
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C₃₅H₅₈O₉ | 88899-55-2 |
Description | |
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Overview | A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409). |
Note: 1 set = 3 x 10 µg | |
Catalogue Number | 196000 |
Brand Family | Calbiochem® |
Product Information | |
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CAS number | 88899-55-2 |
Form | White solid |
Hill Formula | C₃₅H₅₈O₉ |
Chemical formula | C₃₅H₅₈O₉ |
Structure formula Image |
Applications |
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Biological Information | |
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Primary Target | vacuolar type H+ ATPase |
Primary Target IC<sub>50</sub> | 500 pM |
Purity | ≥90% by HPLC |
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