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| Replacement Information |
|---|
| Empirical Formula | CAS # |
|---|---|
| C₃₂H₄₈N₄O₈ • HCl | 467214-21-7 |
| Description | |
|---|---|
| Overview | A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility. |
| Catalogue Number | 100069 |
| Brand Family | Calbiochem® |
| Synonyms | NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG |
| References | |
|---|---|
| References | Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317. Jez, J.M., et al. 2003. Chem. Biol. 10, 361. Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7. |
| Product Information | |
|---|---|
| CAS number | 467214-21-7 |
| ATP Competitive | N |
| Form | Purple solid |
| Hill Formula | C₃₂H₄₈N₄O₈ • HCl |
| Chemical formula | C₃₂H₄₈N₄O₈ • HCl |
| Reversible | N |
| Structure formula Image | |
| Applications | |
|---|---|
| Application | 17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM). |
| Biological Information | |
|---|---|
| Primary Target | 17-DMAG |
| Primary Target IC<sub>50</sub> | GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen |
| Purity | ≥95% by TLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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